ADHD: Low Dopamine ADHD is naturally geared to lower levels of dopamine —the brain chemical that affects motivation, focus, and reward. Daily activities feel less satisfying, such as sports, movies or visiting with friends. When nothing can make you feel better, what is left? Alcohol and other substances stimulate dopamine-releasing neurons , which can enhance the sensation of dopamine release. These substances do not increase dopamine, but rather can make it easier to feel the effect. When you’re struggling to enjoy simple activities at home, being able to briefly feel normal is like a dream