Keep insulin out of direct sunlight and extreme temperatures (colder than 36°F or warmer than 86°F). It will become less effective at these temperatures.

Do not use insulin that is cloudy or has particles in it, or if the pen is full of bubbles.

Open pens or vials:

• Pens and vials are considered open once you put a needle on the pen or in the vial.
• Keep at room temperature.
• Insulin at room temperature is more comfortable than taking chilled insulin and may cause fewer skin irritations. Consider removing a new pen/vial from the refrigerator 30  minutes before you will need to use to allow the insulin to reach room temperature.
• Throw away open pens/vials after 28 days. Insulin becomes less effective 28 days after opening so the pens/vials should be thrown away after that time. Consider making note of the day the pen/vial should be thrown away by writing that date on the pen/vial.

Unopened pens or vials:

• Keep refrigerated until ready to use.
• If traveling with extra pens and temperatures will be greater than 86°F, pack insulin in an insulated container. Do not put in checked luggage if traveling by plane, train, or bus.
• Good until expiration date listed on the box.