Trial
Psychiatry

ITI-007-321: An Open-label, Multicenter Trial to Assess the Safety and Tolerability of Lumateperone in the Treatment of Pediatric Patients with Schizophrenia, Bipolar Disorder, or Autism Spectrum Disorder

Active recruiting
The primary objective is to evaluate the efficacy of lumateperone administered orally for at least 26 weeks in pediatric patients with schizophrenia (aged 13 to 17 years) or pediatric patients with bipolar disorder (aged 10 to 17 years), or pediatric patients with irritability associated with autism spectrum disorder (ASD) (aged 5 to 17 years).
News

ADHD & Substance Abuse: Understanding the link, breaking the cycle

ADHD: Low Dopamine ADHD is naturally geared to lower levels of dopamine —the brain chemical that affects motivation, focus, and reward. Daily activities feel less satisfying, such as sports, movies or visiting with friends. When nothing can make you feel better, what is left? Alcohol and other substances stimulate dopamine-releasing neurons , which can enhance the sensation of dopamine release. These substances do not increase dopamine, but rather can make it easier to feel the effect. When you’re struggling to enjoy simple activities at home, being able to briefly feel normal is like a dream
Locations

SIU Medicine Pediatric Genetics | St. John's Children's Hosptial

415 N. 9th St. Springfield, IL 62701 2nd Floor, Suite 2W106
Mon - Fri: 8:00 am-4:30 pm
Locations

SIU Medicine Pediatric Genetics | St. John's Children's Hosptial

415 N. 9th St. Springfield, IL 62701 2nd Floor, Suite 2W106
Mon - Fri: 8:00 am-4:30 pm
News

Restoring smiles, transforming lives through cleft lip and palate care

A cleft lip or cleft palate, also known as an orofacial cleft, is one of the most common birth defects or malformations. It occurs when a baby’s lip or mouth doesn’t form as expected.
Medical Services

Shoulder Replacement Surgery

Shoulder replacement surgery (called shoulder arthroplasty) removes damaged areas of bone and replaces them with implanted parts made of metal and plastic. The shoulder is a ball-and-socket joint. The round head part of the upper arm bone fits into a shallow socket in the shoulder. Damage to the joint can cause pain, weakness and stiffness. Shoulder replacement surgery is done to relieve pain and other symptoms that result from damage to the shoulder joint. Conditions that can damage the joint include: Osteoarthritis Rotator cuff injuries Fractures Rheumatoid arthritis and other inflammatory
Trial
Psychiatry

ITI-007-601: A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Assess the Efficacy and Safety of Lumateperone in the Treatment of Irritability Associated with Autism Spectrum Disorder in Pediatric Patients 5 to 17 Years of Age

Active recruiting
The primary objective is to evaluate the efficacy of high and low doses of lumateperone vs placebo for the treatment of irritability associated with autism spectrum disorder (ASD) in pediatric patients as measured by the change from baseline to end of Week 6 in the ABC Irritability (ABC-I) subscale score.
Trial
Neurology

Xenon XPF-010-303: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

Active recruiting
The primary objective is to assess the effect of XEN1101 versus placebo on reducing PGTCS frequency in subjects with PGTCS.
Trial
Neurology

Xenon XPF-010-302: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Focal-Onset Seizures

Active recruiting
The primary objective of this study is to assess the effect of XEN1101 versus placebo on reducing focal seizure frequency.
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