Male infertility is a man's inability to cause pregnancy in a fertile female, commonly due to deficiency of sperm cells in the semen. Infertility is a common problem and affects one in every six couples who are trying to conceive. In at least half of all cases of infertility, a male factor is a major or contributing cause. Treatments may be available in the form of medication, hormone therapy, or surgery. SIU Medicine offers a comprehensive approach to male fertility treatment. When to seek care In general, if a man has been trying with a female partner to conceive (engaging in unprotected