The purpose of this study is to investigate the efficacy and safety of tirzepatide in adult participants with Type 1 Diabetes and obesity or overweight.

The purpose of this study is to measure efficacy and safety with baxdrostat compared with placebo in participants with PA. The main objective is to assess the effect of treatment with baxdrostat 2 mg titrated to 4 mg versus placebo on the reduction of SBP and unsuppression of PRA in participants with PA.