Symptoms of Amyloidosis depend on the type of amyloid and the organs affected. AL amyloidosis commonly affects the kidney, and heart gastrointestinal tract, while ATTR amyloidosis affects the heart, nerves and joints. Symptoms due to the heart’s involvement: Difficulty in breathing with minimal walking/exertion Leg and ankle swelling Abdominal swelling Fatigue and weakness Unable to lie flat in bed or sleeping with more pillows due to difficulty in breathing Atrial fibrillation (irregular heart rhythm) Heart blocks Symptoms due to Kidney involvement: Foamy urine – due to increased loss of