Overview

Parkinson’s disease is a progressive disorder that is caused by degeneration of nerve cells in the part of the brain called the substantia nigra, which controls movement. These nerve cells die or become impaired, losing the ability to produce an important chemical called dopamine. Studies have shown that symptoms of Parkinson's develop in patients with an 80 percent or greater loss of dopamine-producing cells in the substantia nigra. 

The cause of Parkinson's essentially remains unknown. However, theories involving oxidative damage, environmental toxins, genetic factors, and accelerated aging have been discussed as potential causes for the disease. In 2005, researchers discovered a single mutation in a Parkinson’s disease gene (first identified in 1997), which is believed responsible for 5 percent of inherited cases. Parkinson's Disease Center

According to the Parkinson’s Foundation, an estimated 60,000 Americans are diagnosed with Parkinson’s disease each year.

Parkinson's Disease Center

The Parkinson's Disease and Movement Disorders Clinic at SIU Medicine provides comprehensive medical, physical and emotional support for individuals with Parkinson disease, Huntington disease, Tourette syndrome, dystonia, blepharospasm, essential tremor, ataxia and other movement disorders.

This innovative clinic offers complete care for the movement disorder patient. The initial screening by neurologists provides complete diagnostic information and treatment plans. Based on this evaluation, the patient may be referred to other specialists to meet each individual's short-term and long-term needs.

While attending the clinic, a continuing relationship with the patient's primary physician is maintained. Patients are provided educational materials and information regarding outside community resources.

Common symptoms

Parkinson’s disease is a progressive nervous system disorder that mainly impacts movement. Parkinson’s disease can also affect sleep, memory and mood. Its symptoms can be different for everyone. Early signs might even be mild. They may even go unnoticed for years. The symptoms of Parkinson’s disease often start on one side of the body and progress to include the other side. 

Common symptoms include: 

  • Tremors
  • Rigid or tight muscles
  • Slowed movement
  • Impaired balance and posture
  • Speech changes
  • Writing changes
  • Loss of automatic movements like smiling and blinking
  • Mood changes
  • Constipation
  • Sleep problems

Treatment options

Medications can help control the symptoms of Parkinson's. Psychiatric treatment may also help alleviate the emotional distress that frequently accompanies the disease.
Movement disorders affect patients and their families in many ways. To meet the needs of each patient, an individual care plan is developed, and may include:

  • Neurologists, specializing in movement disorders, conduct an initial neurological examination as well as provide ongoing treatment
  • Botulinum treatment for dystonia including blepharospasm
  • Genetic counseling and comprehensive evaluation of "at risk" individuals
  • Physical therapists provide rehabilitative treatment for development of ambulatory skills through exercise and gait training
  • Occupational therapists aid in adaptation to self-care activities, work and leisure skills
  • Clinical dieticians help develop diets to meet your specific nutritional needs
  • Health care psychologists address emotional and intellectual adaptations associated with the disability
  • Speech therapists provide treatment aids and family education for speech difficulties
  • Social workers help with personal, social and emotional problems surrounding the disorder
  • A clinical data bank and register of available resources provide complete information
  • Deep brain stimulation procedure

 

Care team

Profiles

Sheena Hoadley, FNP-C

Movement Disorder/DBS Specialist Neurology | Movement Disorders
751 N. Rutledge St. Suite 3100 Springfield, IL 62702
Profiles

Charlene Young, FNP-BC

Certified Nurse Practitioner Neurology
751 N. Rutledge St. Suite 3100 Springfield, IL 62702
Profiles

Whitney Ringer, FNP-BC

Neurology Nurse Practitioner Neurology
751 N. Rutledge St. Suite 3100 Springfield, IL 62702
Profiles

Alessandra Mantovani, MD

Neurosurgeon Neurosurgery
747 N. Rutledge Street 2nd floor Springfield, IL 62702
Profiles

Dale Korinek, Psy.D

Clinical Neuropsychologist Psychiatry
319 E Madison St 3rd Floor Springfield, IL 62702
Profiles

Lauri Lopp, MD

Physician Family Medicine
520 N. 4th St. Springfield, IL 62702

 

Care facilities

Locations
Locations
Locations
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Clinical trials

Trial
Neurology

Phase 2b/3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Safety and Efficacy of Dipraglurant (ADX48621) for the Treatment of Dyskinesia in Patients with Parkinson's Disease Receiving Levodopa-based

Active recruiting

The purpose of this study is to evaluate the effectiveness, safety, and tolerability of the investigational drug, dipraglurant (ADX48621), in subjects with Parkinson’s disease (PD) and levodopa-induced dyskinesia (LID).

 

Trial
Neurology

Roche: A Phase IIB, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of intravenous prasinezumab in participants with early Parkinson's disease

Active not recruiting

This study will evaluate the efficacy, safety, and pharmacokinetics of prasinezumab compared with placebo in patients with early Parkinson's disease (PD).