Epilepsy

    Overview

    Epilepsy is a disorder of the brain that causes repeated, unpredictable seizures, generally beginning in childhood or early adulthood. This condition can lead to serious complications, including injury to the brain.  Epilepsy means the brain has formed abnormal electrical connections that disrupt normal brain function and cause seizures.

    Causes

    It can be caused by genetics or an injury, infection or illness to the brain, such as a stroke or brain tumor.  Epilepsy can be caused by unknown reasons which occur in around half of cases.

    Treatment

    In adults, medication can frequently control epilepsy. However, if seizures persist after trying two drugs, our expert neurosurgeons may offer epilepsy surgery. Surgical treatment may be considered if your seizures continue after trying two different medications.  Your neurosurgeon offers a diagnostic surgery for detection of difficult to localize seizures, also called intracranial EEG monitoring – this is to localize the seizure area and to map brain function. 

    Surgical Procedures

    A craniotomy is performed and sterile EEG leads are placed directly on the brain.  The bone flap is placed back on the patient and secured.  The wound is then closed with the tails of the EEG leads coming out through the wound.  These leads are connected to EEG monitors that are available in special rooms in the hospital.  The patient is then monitored continuously for several days for seizure activity.  

    There are several types of treatment surgery for adults:

    • Craniotomy, resection of seizure focus (removing abnormal brain areas) is considered if:
      • Your seizures are continuing after trying two different medications.
      • Your seizures arise from one site in the brain.
      • The site of the seizures has been pinpointed.
      • The removal of the portion of the brain causing the seizures will not impair your ability to function.
    • Vagus nerve stimulation (placing an implant in the neck to help prevent seizures)
    • Corpus callostomy (disrupting connections between the two sides of the brain)

    Our providers

    Profiles

    Jayant Acharya, MD

    Neurologist and Epilepsy Specialist Neurology
    751 N. Rutledge St. Suite 3100 Springfield, IL 62702
    Profiles

    Hossam AbdelSalam, MD

    Pediatric Neurologist Pediatrics
    400 N. 9th Street Springfield, IL 62702
    Profiles

    Abdullah Al Sawaf, MD

    Neurologist Neurology
    751 N. Rutledge St. Suite 3100 Springfield, IL 62702
    Profiles

    Jeffrey Cozzens, MD

    Neurosurgeon Neurosurgery, Cancer Care
    747 N. Rutledge Street 2nd floor Springfield, IL 62702
    Profiles

    Jose Espinosa, MD

    Neurosurgeon Neurosurgery
    747 N. Rutledge Street 2nd floor Springfield, IL 62702
    Profiles

    Faisal Ibrahim, MD

    Neurologist Neurology
    751 N. Rutledge St. Suite 3100 Springfield, IL 62702
    Profiles

    Dale Korinek, Psy.D

    Clinical Neuropsychologist Psychiatry
    319 E Madison St 3rd Floor Springfield, IL 62702
    Profiles

    Alessandra Mantovani, MD

    Neurosurgeon Neurosurgery
    747 N. Rutledge Street 2nd floor Springfield, IL 62702
    Profiles

    Jacob Monsivais, PA-C

    Certified Physician Assistant Neurology
    751 N. Rutledge St. Suite 3100 Springfield, IL 62702
    Profiles

    Sajjad Mueed, MD

    Director, Memorial Medical Center Stroke Center Neurology
    751 N. Rutledge St. Suite 3100 Springfield, IL 62702
    Profiles

    Nitin Patel, MD

    Pediatric Neurologist Neurology, Pediatrics
    400 N. 9th Street Springfield, IL 62702
    Profiles

    Whitney Ringer, FNP-BC

    Neurology Nurse Practitioner Neurology
    751 N. Rutledge St. Suite 3100 Springfield, IL 62702
    Profiles

    Mehul Trivedi, PhD

    Clinical Psychologist Psychiatry
    319 E Madison St 3rd Floor Springfield, IL 62702

    Why SIU

    Continually learning

    With a focus on continual improvement, our doctors take the time to research, study and innovate to provide the latest treatments for our patients.

    Patient-first experience

    Our care ranges from primary care physicians to specialists and sub-specialists who have advanced training. We're here for you when you need us.

    Breakthrough tech

    Continually teaching the next generation of doctors, our physicians use the latest developments in procedures and technologies for our patients.

    Clinical Trials

    Trial
    Neurology

    A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

    Active recruiting

    The primary objective is to assess the effect of XEN1101 versus placebo on reducing PGTCS frequency in subjects with PGTCS.

    Trial
    Neurology

    A Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Focal-Onset Seizures

    Active recruiting

    The primary objective of this study is to assess the effect of XEN1101 versus placebo on reducing focal seizure frequency.

    Trial
    Neurology

    An Open-Label, Multicenter, Outpatient Extension Study to Evaluate the Safety and Tolerability of Staccato Alprazolam in Study Participants 12 Years of Age and Older with Stereotypical Prolonged Seizures

    Active recruiting

    The primary endpoint of this study is to evaluate the long-term safety and tolerability of Staccato alprazolam.

    Trial
    Neurology

    A Double-Blind, Randomized, Placebo-Controlled, Multicenter, Outpatient, Parallel-Group Study to Assess the Efficacy and Safety of Staccato Alprazolam in Study Participants 12 Years of Age and Older with Stereotypical Prolonged Seizures

    Active recruiting

    The purpose of this study is to compare the success of a single admnistration of Staccato alprazolam compared with placebo in rapidly terminating a seizure episode within 90seconds after IMP administration.

    Trial
    Neurology

    Safety and Therapeutic Measures of Transcranial Cathodal Direct Current Stimulation (TDCS) in Patients with Refractory Focal Epilepsy

    Active recruiting

    The purpose of this study is to evaluate efficacy, safety, and tolerability of repeated, daily sessions of transcranial cathodal direct current stimulation (tDCS).

    Latest articles

    Jayant Acharya

    Acharya named Neurology chair and co-director of SIU Neuroscience Institute

    Dr. Jayant Acharya has been named the chair of the Department of Neurology and co-executive director of the Neuroscience Institute at Southern Illinois University School of Medicine.