Alzheimer's Disease

    Overview

    Alzheimer's disease is a progressive neurological disease that attacks memory and other important brain functions. The Dale and Deborah Smith Center for Alzheimer's Research and Treatment at SIU Medicine provides focused treatment and therapy for the physical and emotional needs of patients and families suffering from this disease.

    Alzheimer's Center

    SIU Medicine is home to the Dale and Deborah Smith Center for Alzheimer's Research and Treatment. 

    Our doctors

    Provider

    Thomas Ala, MD

    Medical Director of the Alzheimer's Center Neurology
    751 N. Rutledge St. Suite 3100 Springfield, IL 62702
    Provider

    Priyanka Bhandari, MD

    Family Medicine
    520 N. 4th St. Springfield, IL 62702
    Provider

    Ann Jirmasek, BS, MA, LPC, NCC

    Clinical Gerontology Specialist Neurology
    751 N. Rutledge St. Suite 3100 Springfield, IL 62702
    Provider

    Lauri Lopp, MD

    Family Medicine
    520 N. 4th St. Springfield, IL 62702
    Provider

    Paula Mackrides, DO

    Family Medicine
    612 N. 11th St. Quincy, IL 62301
    Provider

    Andrea Perkins, FNP-BC

    Certified Nurse Practitioner Neurology
    Provider

    Eukesh Ranjit, MD

    Family Medicine
    520 N. 4th St. Springfield, IL 62702
    Provider

    Ankit Sharma, MD

    Family Medicine
    520 N. 4th St. Springfield, IL 62702
    Provider

    Zachary Sims, PA-C

    Family Medicine
    520 N. 4th St. Springfield, IL 62702
    Provider

    Mehul Trivedi, PhD

    Clinical Psychologist Psychiatry
    319 E Madison St 3rd Floor Springfield, IL 62702
    Provider

    Cindy Womack, DNP, FNP-BC, CNRN

    Certified Nurse Practitioner Neurology
    751 N. Rutledge St. Suite 3100 Springfield, IL 62702
    Provider

    Charlene Young, FNP-BC

    Certified Nurse Practitioner Neurology
    751 N. Rutledge St. Suite 3100 Springfield, IL 62702

    Why SIU

    Continually learning

    With a focus on continual improvement, our doctors take the time to research, study and innovate to provide the latest treatments for our patients.

    Patient-first experience

    Our care ranges from primary care physicians to specialists and sub-specialists who have advanced training. We're here for you when you need us.

    Breakthrough technology

    Continually teaching the next generation of doctors, our physicians use the latest developments in procedures and technologies for our patients.

    Clinical Trials

    Trial
    Neurology

    Roche: An open-label, multicenter, rollover study to evaluate the safety, tolerability, and efficacy of long-term gantenerumab administration in participants with Alzheimer's disease

    Active recruiting

    POST GRAD: The purpose of this study is to compare the effects, good or bad, of long term gantenerumab on subjects with prodromal or mild Alzheimer's disease. 

    Trial
    Neurology

    Caregiver Characteristics That May Predict When Patients With Alzheimer Disease Are Placed in Long Term Care Facilities

    Active recruiting

    This research will be conducted by the SIU Memory and Aging Network (MAN), which comprises 38 sites that evaluate and treat patients with dementia throughout non-metropolitan Illinois.  AD patients and their caregivers who are living in private homes will be recruited.  Primary outcome measures will be the ratings of the caregiver’s physical status (grip strength, walking speed, and score on the Timed Up-and-Go Test11 and the rating of the caregiver’s chronic medical illness burden using the Cumulative Illness Rating Scale (Geriatric).12,13  The patient and caregiver dyad will be encouraged

    Trial
    Neurology

    Lilly: Assessment of Safety, Tolerability, and Efficacy of Donanemab in Early Symptomatic Alzheimer's Disease

    Active not recruiting

    I5T-MC-AACI: Alzheimer’s is a disease that attacks the brain, causing problems with memory, thinking, and behavior.  Symptoms usually develop slowly and get worse over time, eventually making daily tasks impossible. Although we don’t know the exact cause, researchers found out that the two proteins called tau and amyloid are building up in brains of people with Alzheimer’s disease even before they have any symptoms.

    Trial
    Neurology

    Lilly: Assessment of Safety, Tolerability, and Efficacy of Donanemab in Early Symptomatic Alzheimer's Disease

    Active not recruiting

    I5T-MC-AACI: Alzheimer’s is a disease that attacks the brain, causing problems with memory, thinking, and behavior.  Symptoms usually develop slowly and get worse over time, eventually making daily tasks impossible. Although we don’t know the exact cause, researchers found out that the two proteins called tau and amyloid are building up in brains of people with Alzheimer’s disease even before they have any symptoms.

    Trial
    Neurology

    Athira: A Randomized, Placebo-Controlled, Double-Blind, Dose-Ranging Study to Evaluate Safety and Efficacy of ATH-1017 Treatment in Alzheimer’s Dementia Patients

    Active recruiting

    ATH-1017-AD-201: The purpose of this study is to compare the effects, good or bad, of ATH-1017 on patients with mild to moderate Alzheimer's Disease.

    Trial
    Neurology

    Athira: A Randomized, Placebo-Controlled, Double-Blind, Dose-Ranging Study to Evaluate Safety and Efficacy of ATH-1017 Treatment in Alzheimer’s Dementia Patients

    Active recruiting

    ATH-1017-AD-201: The purpose of this study is to compare the effects, good or bad, of ATH-1017 on patients with mild to moderate Alzheimer's Disease.

    Latest articles

    November is Alzheimer's Awareness Month

    In the News November is Alzheimer’s Awareness Month, helping bring awareness to the progressive brain disease that affects memory, language and thought. Dr. Erin Hascup, director of the Dale and

    Introducing the Dale and Deborah Smith Center

    A major gift to SIU School of Medicine will transform the health care of people throughout Illinois and beyond. Springfield couple Dale and Deborah Smith donated a substantial financial gift to the
    Bain Scan

    SIU School of Medicine receives major gift for Alzheimer's research

    A major gift to Southern Illinois University School of Medicine will transform the health care of people throughout Illinois and beyond. Dale and Deborah Smith recently donated a substantial financial